The Cardiovascular Effects of Orchiectomy Versus LHRH Agonists

Jeremy Y.C. Teoh, MBBS, FRCSEd, FCSHK, FHKAM, Assistant Professor at the Chinese University of Hong Kong, outlines the increased risk of cardiovascular events associated with patients undergoing bilateral orchiectomy compared to patients treated instead with luteinizing hormone-releasing hormone (LHRH) agonists or antagonists. He discusses an important study that confirmed the increase in these events for men undergoing orchiectomy. Dr. Teoh continues by discussing another study, on which he was the lead investigator, that confirmed that orchiectomy conferred increased risk of ischemic stroke or myocardial infarction versus LHRH agonists in Chinese men. He concludes that the lower level of testosterone in men undergoing orchiectomy as well as the rise in follicle-stimulating hormone (FSH) levels may be contributing factors in the heightened cardiovascular risk of this procedure.

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