In My Opinion: Biomarkers for the Diagnosis of Prostate Cancer

Posted by Michael A. Gorin, MD | Dec 2020

Michael A. Gorin, MD, presented “In My Opinion: Biomarkers for the Diagnosis of Prostate Cancer” virtually during the Perspectives in Urology: Point Counterpoint 2020 virtual conference in November 2020.

How to cite: Gorin, Michael A. “In My Opinion: Biomarkers for the Diagnosis of Prostate Cancer” September 26th, 2020. Accessed Apr 2024. https://dev.grandroundsinurology.com/in-my-opinion-biomarkers-for-the-diagnosis-of-prostate-cancer/

Summary:

Michael A. Gorin, MD, a urologist with Urology Associates in Cumberland, Maryland, discusses biomarkers for diagnosing prostate cancer, including PSA, mpMRI, and serum and urine tests. He gives an overview of the history of prostate specific antigen (PSA), emphasizing that PSA screening is beneficial even as he acknowledges that PSA’s high sensitivity and low specificity result in many unnecessary biopsies. There are now many serum and urine biomarker tests that can help provide more specificity, including 4KScore, Prostate Health Index, SelectMDx, and ExoDx Prostate IntelliScore (EPI), all of which are endorsed by the NCCN Guidelines. Dr. Gorin notes that, when price is considered, SelectMDx and EPI outperform the other tests. Dr. Gorin concludes the presentation by discussing how multiparametric MRI should be used in prostate cancer diagnosis, noting that while there is little official guidance on this yet, he uses it in his own practice if a patient has a PSA ≥3 and receives an abnormal result from a serum or urine biomarker test.

About the Perspectives in Urology: Point Counterpoint 2020 virtual conference:
Presented by Program Chair and Grand Rounds in Urology Editor-in-Chief E. David Crawford, MD, as well as Program Co-Chair Dan Theodorescu, MD, PhD, this virtual conference brought together leading experts in urology, medical oncology, and radiation oncology to discuss and debate the latest topics in genitourinary cancers, primarily prostate cancer and bladder cancer. This two-day interactive conference offered topical lectures, pro/con debates, interesting-case presentations, interactive panel discussions, and interactive audience and faculty networking. A focus on prostate cancer was given on Wednesday, November 11th, with a focus on bladder cancer given on Thursday, November 12th.

About The Author

Michael A. Gorin, MD

Dr. Gorin is a fellowship-trained minimally invasive urologist based in Western Maryland. He is also the Director of Medical Affairs for Perineologic, maker of the PrecisionPoint Transperineal Access System. Dr. Gorin’s clinical practice focuses on adult general urology with a special interest in caring for patients with kidney stones, benign prostatic hyperplasia (BPH), and prostate cancer. Dr. Gorin is considered as a thought leader in the field for his research on molecular imaging of genitourinary cancers. He is also widely known for his work developing novel methods for performing MRI-guided transperineal prostate biopsy and focal cryoablation ablation of the prostate. Dr. Gorin has published over 225 articles in peer-reviewed journals and has contributed to multiple medical textbooks, including chapters in Campbell-Walsh-Wein Urology, The 5-Minute Urology Consult, and Gray’s Anatomy. Dr. Gorin also serves on the editorial boards of several journals including UROLOGY (the Gold Journal), British Journal of Urology International, and World Journal of Urology and has received numerous honors and awards for his scholarly work. Dr. Gorin attended college at the University of Michigan where he earned a Bachelor of Science in Cellular and Molecular Biology. He then went on to attend medical school at the University of Miami Leonard M. Miller School of Medicine where he graduated as an inductee to the Alpha Omega Alpha Honor Medical Society. Following medical school, Dr. Gorin completed a general surgery internship, urology residency, and a fellowship in endoscopic and minimally invasive urology at Johns Hopkins University School of Medicine. Dr. Gorin earned a Bachelor of Science in Cellular and Molecular Biology from the University of Michigan in Ann Arbor. He then went on to attend medical school at the University of Miami Leonard M. Miller School of Medicine, where he graduated as an inductee to the Alpha Omega Alpha Honor Medical Society. Following medical school, Dr. Gorin completed a general surgery internship, urology residency, and fellowship in endoscopic and minimally-invasive urology at Johns Hopkins University School of Medicine.

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