Topic: Biomarkers

Industry Perspective: The Role of URO17 TM in the Diagnosis and Management of Bladder Cancer

John Cucci, an executive at Acupath Laboratories, Inc., introduces the URO17TM antibody, a promising adjunct to cytology for bladder cancer diagnosis. Mr. Cucci explains that while cytology is the standard technique used in diagnosing bladder cancer and has a high positive predictive value, its sensitivity is low. URO17TM detects the expression of keratin-17, a protein strongly associated with bladder cancer, and has greater than 95% sensitivity and specificity. Mr. Cucci goes over the promising early results for URO17TM, as discussed in several papers, and notes that it has been given an expedited clinical trial process by the FDA. He also looks at its potential clinical utilization, both as a screening tool for hematuria patients and as a long-term monitoring tool for bladder cancer patients after they complete therapy. He emphasizes that URO17TM can cheaply and effectively provide additional and reliable information for the pathologist and urologist to more appropriately rule in or out additional diagnostic work-up in patients. Mr. Cucci concludes by presenting a graphic of the URO17TM diagnosis categories and risk meter.

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Industry Perspective: Panel Discussion on Cxbladder Genomic Urine Test for Bladder Cancer

Siamak Daneshmand, MD, Associate Professor of Urology and Director of Clinical Research at the University of Southern California (USC), along with Anne Schuckman, MD, Assistant Professor of Clinical Urology at the USC, and Sima P. Porten MD, MPH, Associate Professor at the USC participated in a panel discussion on the Cxbladder Genomic Urine Test for Bladder Cancer at the 5th Annual International Bladder Cancer Update. Dr. Daneshmand reviews a research study that audited the clinical utility of the Cxbladder monitor assay and found that it accurately ruled out patients who did not have recurrent UC, enabling low risk patients to undergo cystoscopy at a longer-than-recommended interval, thereby reducing the cystoscopy burden by 39%. He then asks Drs. Porten and Schuckman questions about their experience with Cxbladder, leading the two to discuss ideal patient populations for Cxbladder, in-home sampling procedures, and situations wherein Cxbladder is most effective.

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Bladder Cancer Journal Vol. 6, Issue 4

Upregulated FGFR3 signaling in NMIBC and MIBC, the diagnosis and management of checkpoint inhibitor side effects in bladder cancer patients, the etiology of treatment delays in patients receiving neoadjuvant chemotherapy for MIBC, and 25-year trends in stage-specific incidence rates for bladder cancer.

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PC Markers Algorithm

E. David Crawford, MD, Editor-in-Chief of Grand Rounds in Urology and Professor of Urology at University of California, San Diego, discusses how the PC Markers algorithm simplifies the process of screening, diagnosing, and treating prostate cancer for primary care physicians and urologists. Family practitioners and internists order 90% of PSA tests in men, but may be overwhelmed with other health concerns in their patients when deciding to refer them to urologists. Dr. Crawford discusses data behind the identification of PSA >1.5ng/ml as the trigger point for screening, with a significant increase in cancer diagnosis between 1.5-4.0ng/ml. He also notes that 73% of PSA tests are still below the 1.5ng/ml threshold of eligibility for further PCa screening. Dr. Crawford then details the development of the PC Markers algorithm and how it combines a range of blood, urine, and imaging biomarkers to better inform primary care physicians and urologists in how to proceed with prostate cancer screening, diagnosis, and treatment.

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Prevalence of Criteria for Genetic Testing According to the National Comprehensive Cancer Network Guidelines in a Contemporary Cohort of Post-Prostatectomy Men with Intermediate and High-Risk Prostate Cancer: The Henry Ford Health System Experience

Zade Roumayah details the results of a study at the Henry Ford Health System examining the prevalence of National Comprehensive Cancer Network criteria for genetic testing in post-prostatectomy men who had intermediate- to high-grade prostate cancer. With around a 50% response rate, the team found that around 27% of men fit these criteria, in categories including family history of break & ovarian cancer, having two or more family members with a variety of cancer types, and personal cancer history.

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Associate Editors


Fred Bartlit, Esq.
StrongPath


Mark A. Moyad, MD, MPH
University of Michigan
Ann Arbor, Michigan