nmCRPC: Is Navigating the M0 Space the Next Moon Shot?
E. David Crawford, MD, presented this lecture during the 28th Annual Perspectives in Urology: Point-Counterpoint on November 16, 2019, in Scottsdale, New Arizona.
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Researcher-physician E. David Crawford, MD, has devoted his career in medicine to educating the public about men's health issues and finding effective techniques and procedures to address prostate cancer, the most common malignancy affecting men in the United States.
He is currently a Professor of Urology at the University of California, San Diego, and emeritus distinguished endowed Professor of Surgery, Urology, and Radiation Oncology, and Head of the Section of Urologic Oncology at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. Dr. Crawford received his medical degree from the University of Cincinnati and his postgraduate training included an internship and residency in urology at the Good Samaritan Hospital in Cincinnati. He subsequently completed a genitourinary cancer fellowship at the University of California Medical Center in Los Angeles.
Dr. Crawford is an internationally recognized expert in benign prostate hypertrophy, urologic cancers, and in particular, prostate cancer. He has conducted research in the treatment of advanced bladder cancer, metastatic adenocarcinoma of the prostate, hormone-refractory prostate cancer, and other areas of urological infections and malignancies. He has authored or coauthored over 810 scientific articles, has published seven textbooks, authored over 60 book chapters, and provided more than 2,200 educational talks for patients and physicians.
In an effort to raise public awareness about prostate health, Crawford in 1989 founded the Prostate Conditions Education Council (PCEC). The non-profit organization is comprised of a consortium of leading physicians, health educators, scientists, and men's health advocates. PCEC's advocacy for free or low-cost prostate screening has affected the lives of millions of American men. He currently chairs the PCEC.
Crawford is an active member of many national and international organizations, including the American Society of Clinical Oncology, the American Urological Association (AUA), and the American Association for the Advancement of Science. Within the AUA, he has been a member of the Committee to Study Urologic Research Funding and the prostate cancer clinical trials subcommittee. Crawford served on the board of governors, the scientific advisory board of the Southwest Oncology Group, and was chairman of the Genitourinary Cancer Committee for 27 years. This group is the largest clinical trials group in the world.
Crawford's involvement in the national prostate cancer arena has been widely recognized. He has received many honors and awards, including the CAP Cure Annual Award for Scientific Presentation in 1999 In 1997, he was presented with a 'Freddie Award" at the AMA International Health and Medical Film Competition for the program, ITV: The Cutting Edge Medical Report (Prostate Cancer: Understanding, Diagnosing, and Defeating), which Crawford hosted with special guest, retired General Norman Schwarzkopf.
Crawford again won a prestigious 'Freddie Award" 5 years ago... He is a member of Best Doctors of America and was named Healthcare Provider of the Year in the Denver Metro area by the Denver Business Journal.
He has been recognized as one of the Best Doctors of America for the past two decades and is recognized as one of the top 20 urologists in the country, for men, by Men’s Health Magazine. In 2018 he received the honor of being named the Distinguished Alumnus of the Year from the University of Cincinnati School of Medicine. In May of 2019, he received the Presidential citation from the American Urological Association recognizing for his “tireless role in genitourinary cancer research that has benefited countless urologic cancer patients.” He accepted the position of Editor in Chief of Grand Rounds in Urology in June of 2019. In 2021, he was the recipient of the Merle Stringer, M.D. annual award for excellence in medicine by the Florida State Medical Association.
Disclosures:Posted by E. David Crawford, MD | Dec 2019
E. David Crawford, MD, presented this lecture during the 28th Annual Perspectives in Urology: Point-Counterpoint on November 16, 2019, in Scottsdale, New Arizona.
Read MorePosted by E. David Crawford, MD | Nov 2019
E. David Crawford, MD, reviews the findings and recommendations from the Radiographic Assessments for Detection of Advanced Recurrence (RADAR) III working group, and how its prior iterations, RADAR I and II, provided the rationale for the RADAR III manuscript. He discusses the next generation imaging modalities and radiotracers covered in RADAR III, as well as the group’s consensus on how they should be implemented in the evaluation of patients with prostate cancer.
Read MorePosted by E. David Crawford, MD | Jul 2019
E. David Crawford, MD, argues for using PSA levels of 1.5 ng/mL as the cutoff point for determining prostate cancer risk in routine screening. He discusses the need for utilizing better risk-assessment methods for detecting prostate cancer, such as genomic markers, in order to reduce unnecessary biopsies, over-detection of indolent disease, and reliance on PSA testing alone.
Read MorePosted by E. David Crawford, MD | Jul 2019
E. David Crawford, MD, explains the role of testosterone, the androgen receptor (AR), and AR signaling pathways in prostate cancer. He discusses various available androgen deprivation therapies, including third generation androgen pathway inhibitors, and notes the importance of tailoring therapy to individual patients.
Read MorePosted by E. David Crawford, MD | Jun 2019
E. David Crawford, MD, discusses the concept of disruptive technologies—developments which displace established technology or create entirely new industries—in the context of prostate cancer treatment and diagnosis. He reviews new and developing technologies transforming prostate cancer care, and discusses how they can be constructive as well as destructive.
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