Dr. Seth Lerner and Dr. Daniel Petrylak, both experts in the clinical area of bladder cancer, provide analysis of treating this common cancer and its future prospects.
Presentation:
In this issue of Grand Rounds in Urology, two leading experts in the clinical area of bladder cancer will provide analysis of treating this common cancer and its future prospects. According to recent statistics, bladder cancer is the fourth most common type of cancer in men and the eighth most common in women. Each year in the United States, more than 70,000 men and women combined are diagnosed with bladder cancer. More than 90% of patients with bladder cancer (both men and women) have a transitional cell cancer (TCC), and unfortunately current chemotherapeutic agents for advanced or metastatic disease rarely result in cure.. Additionally, bladder cancer is one of the most costly cancers to treat, more costly than lung cancer, more than breast cancer, and more costly than colon cancer. It is expected that the incidence of bladder cancer will continue to increase, and most of the surviving patients will require frequent follow up and treatment.
In the first article, Dr. Seth Lerner, from Baylor College of Medicine, discusses a number of challenges in managing localized disease , including intra- vesical therapy and endoscopic imaging. Since this field is moving fairly quickly, Dr. Lerner provides the reader with some tools that might answer the question as to why wouldn’t you want to see better at the time of cystoscopy. The discussion covers issues like fluorescence, narrow- band imaging, and optical coherence tomography as well as drug therapy, and we hope it will offer valuable ideas on how to provide a more complete diagno- sis and comprehensive therapy.
The second article is from Dr. Daniel Petrylak, from Columbia University, who provides his analysis a systemic approach to treatment. Of important emphasis is how understanding biology can help in the development of future clinical trials. Dan discusses adjuvant and neoadjuvant therapy, antiangiogentics agents, and the prospect of vaccines among the ongoing variety of approaches. His thorough review suggests there is an utmost need for collaborative clinical trials to find new ways to attack this difficult to treat and deadly disease.
Keywords: bladder cancer, localized disease, intra- vesical therapy, endoscopic imaging, cystoscopy, fluorescence, narrow-band imaging, optical coherence tomography, drug therapy, adjuvant therapy, neoadjuvant therapy, antiangiogentics agents, vaccines
How to cite: Lerner, Seth, and Daniel P. Petrylak. “Bladder Cancer: Advances in Diagnosis and Clinical Care.” Grand Rounds in Urology. January 19, 2015. Accessed Dec 2024. https://dev.grandroundsinurology.com/bladder-cancer-lerner-petrylak-diagnosis/.
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ABOUT THE AUTHOR
Seth P. Lerner, MD, is a Professor of Urology and holds the Beth and Dave Swalm Chair in Urologic Oncology in the Scott Department of Urology at Baylor College of Medicine. He is also Director of Urologic Oncology and the Multidisciplinary Bladder Cancer Program and Faculty Group Practice Medical Director for the Urology Clinic at Baylor. He earned his medical degree from Baylor College of Medicine, completed a surgical internship at Virginia Mason Hospital in Seattle, and returned to Baylor for his residency training. He completed a two-year fellowship at the University of Southern California in Urologic Oncology and Reconstructive Surgery under Peter Jones and Don Skinner before returning to join the full-time Baylor faculty in 1992. His clinical practice, education, and research activities are devoted to urologic oncology, particularly lower and upper tract urothelial cancer. Dr. Lerner is an author on over 190 peer-reviewed articles, and co-editor of the comprehensive Textbook of Bladder Cancer. He is the founding Co-Editor-in-Chief of the Bladder Cancer journal. He established and directs the multi-disciplinary Bladder Cancer Research Program at Baylor, and his research interests include the use of selective estrogen receptor modulators for the treatment of bladder cancer, gene therapy, integrated genomic analysis of bladder and upper urinary tract cancers, and outcomes of radical cystectomy and pelvic lymphadenectomy. He has 25 years of experience as a clinical investigator for both NCI and industry-funded clinical trials. He is the PI of the ongoing SWOG NCI Phase III trial comparing extended vs. standard pelvic lymphadenectomy at the time of radical cystectomy. He is Chair of the Local Bladder Cancer Committee of SWOG, founding and former Co-Chair of the NCI Bladder Cancer Task Force and current Co-Chair of the NCI CTEP Genitourinary Steering Committee, and he has co-chaired the Analysis Working Group of The Cancer Genome Atlas Project for muscle-invasive bladder cancer for the past decade. He is very active in the Bladder Cancer Advocacy Network (BCAN) as a member of the Board of Directors, and is Past Chair of the Bladder Cancer Think Tank and Co-Chair of the Management Committee of the Bladder Cancer Research Network. Dr. Lerner is an active member of the prestigious American Association of Genitourinary Surgeons and is listed routinely among “America’s Top Doctors” and “Best Doctors in America.”
